By Wojciech Gorczyca
This large reference overlaying neoplastic hematopathology comprises over 500 color illustrations depicting hematopoietic tumors concerning lymph nodes, spleen, bone marrow, and in general affected extranodal organs, with precise emphasis at the differential prognosis. It discusses uncomplicated scientific, prognostic, morphologic and phenotypic information, with quite a few tables summarizing the phenotypic profiles of the most typical hematologic tumors. an enormous characteristic of this ebook is an method of hematologic tumors according to the WHO category, with appropriate examples and emphasis at the most precious morphologic and immunophenotypic positive aspects utilized in diagnosis.It can be a useful reference for all practicing hematologists, oncologists and pathologists.
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Extra resources for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
CD3, CD5), CD10, CD21 (to assess the dendritic cells) and bcl-2 helps to identify normal architecture and differentiate reactive process from lymphoma. 22C–F shows a normal pattern of immunohistochemical staining with selected relevant markers. 2) t(12;21)(p13;q22) del(1p32) del(9p); others Allelic loss of 7q(21–32) Trisomy 3 t(14;18)(q32;q21) t(2;18)(p12;q21) Trisomy 12 B-ALL T-ALL Splenic marginal zone lymphoma Follicular lymphoma B-SLL/CLL BCR-ABL Poor prognosis fusion gene TAL1 deletion BCL2-IGGH Atypical morphology and poor prognosis Mantle cell lymphoma Diffuse large B-cell lymphoma Marginal zone B-cell lymphoma (MALT) Burkitt’s lymphoma t(11;14) t(3;14) BCL1-IGGH BCL6-IGGH t(11;18) API1-MALT1 t(8;14,2, or 22) Anaplastic large cell lymphoma Chronic myelomonocytic leukemia Myelodysplastic syndrome (MDS) MDS with isolated del(5q) t(2;5)(p23;35) t(1;2)(a25;p23) +8, −7/del(7q), t(5;12) MYC-IGH, IGK, or IGL NPM-ALK del(20q), +8, abnormalities of chromosome 5 and/or 7 del(5q) only Good prognosis TEL-PDGFβR 5q (−) syndrome Bone marrow The bone marrow in the adult occupies the medullary spaces of large bones such as the femur, the hip, the sternum and the humerus.
The recognized morphologic maturation stages in granulocytic lineage are blasts, promyelocytes, myelocytes, metamyelocytes, bands and polymorphonuclear leukocytes (neutrophils). 24B). 24C) are scattered individually, and usually do not exceed 4–5 per high-power field (objective×40). Cytoplasmic fragments of megakaryocyte cells (platelets) are instrumental in primary hemostasis. The erythroid lineage matures from stem cell to red cells (which carry oxygen to peripheral tissues) through proerythroblast (pronormoblast), early normoblast (basophilic erythroblast), intermediate normoblast (polychromatic erythroblast), late normoblast (orthochromatic erythroblast) and reticulocyte.
13 shows FC findings in a case of partial lymph node involvement by malignant lymphoma. A histologic section shows a lymph node with reactive follicles (*) and a focus of follicular lymphoma (A; arrow). FC (B and C) shows two populations of B-cells: those with moderate expression of CD20 (*) and those with bright expression of CD20 (arrow). The latter are monoclonal lambda+ cells, representing follicular lymphoma. Residual benign B-cells with moderate CD20 expression are polytypic (compare B and C).