Advances in Immunity and Cancer Therapy: Volume 1 by P. K. Ray

By P. K. Ray

The fast and non-stop upsurge of attention-grabbing information within the topic of tumor immunology necessitates the e-book of an annual sequence to provide the up-to-date fabrics to the scholars, researchers, and clinicians during this swiftly advancing box. suggestions and methodologies are ever altering. additionally, present examine in tumor immunology offers to provide breakthroughs sooner or later. very important is the necessity to converse to the best humans the precise function of immunodiagnostic equipment and immunolog­ ical intervention in melanoma prevention and therapy. The function of immuno­ treatment together with traditional modalities of therapy wishes in its right point of view. Oncogene, interferon, lympho­ to be understood kines, monoclonal antibodies, traditional killer cells, platelet-mediated cyto­ toxicity of antibody-coated objective cells, suppressor cells, platelet-derived elements, plasma-blocking elements, keep an eye on of suppressor cellphone functionality, ab­ rogation of plasma-blocking components, and so forth. , are the various parts which are regularly advancing. development in those parts could have implication in melanoma treatment. extra, it really is already understood that if immunocompe­ tence of the host could be maintained at a fairly reliable point, there exists the aptitude to extend the healing indexes of traditional modalities of therapy. This sequence will try to current up-to-date infor­ mation in some of these components in keeping with contributed and solicited articles. P. K.

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Thus, immune reactions involve a complex network of interacting factors and are ultimately dependent on the antigenicity and immunogenicity of the tumor. There is growing evidence that malignant cells contained in primary tumors may be heterogeneous with regard to a number of their characteristics, including metastatic potential, chemotherapeutic responsiveness, radiosensitivity, metabolic properties, growth rate, hormone receptors, pigment production, and immunogenicity (1-3). Contact between an antigen and a lymphocyte receptor can have any one of a number of outcomes, including activation, tolerance induction, blockade of receptors, induction of helper activity, induction of suppression, or none of these, depending on a multitude of operational variables.

Before resorting to use of cytotoxic agents such as chemotherapeutic drugs or radiation, it is essential to understand that the immune status of the tumor-bearing host; cytotoxic agents do compromise the immune status of the host. Proper evaluation of the immunologic profile of a patient allows the advantage of choosing an appropriate modality of treatment and helps us to avoid the deleterious effects of chemotherapeutic agents through proper circumvention. This consideration is all the more important when we are resorting to circumvention by immunotherapeutic means, because we cannot assume that the understanding we have gained about these procedures from normal recipients would be properly comparable to a host bearing an autochthonous neoplasm (105-109).

Phys. 2:289, 1977. 105. : Int. J. Radiat. Oneol. BioI. Phys. 6:471, 1980. 106. : Int. 1. Radiat. On col. BioI. Phys. 5:49, 1979. 107. : Clin. Exp. Immunol. 38:366, 1979. 108. : Int. 1. Radiat. Oncol. BioI. Phys. 4:249, 1978. 109. : Anticancer Research 2:209, 1982. 110. : Radiother. Oncology, 1:255, 1984. Ill. : Clin. Exp. Immunol. 22:230, 1975. 112. : 1. Clin. Lab. Immunol. 1 :73, 1978. 113. : Eur. 1. Cancer Clin. Oncol. 18:637, 1982. 114. : Anticancer Research 3:41, 1983. 115. : Acta Radiol. Oncol.

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